Kerala’s entrepreneurship culture has changed dramatically, becoming a thriving ecosystem that encourages creativity and company expansion. Kerala’s history of trade and business has a strong influence on its entrepreneurial culture. Numerous family-owned businesses that have been handed down through the generations are part of the state’s lengthy history of business. The state’s economy has been greatly influenced by these traditional companies, which have also laid the groundwork for contemporary entrepreneurship. The existence of excellent educational establishments, such as medical and engineering schools, has produced a pool of bright and capable individuals who are prepared to launch their own companies. Through the Kerala Startup Mission (KSUM), the government of Kerala launched the startup movement by developing and enforcing policies aimed at establishing a thriving startup ecosystem in the state. Kerala’s entrepreneurial culture is a vibrant, ever-changing environment propelled by creativity, social responsibility, and a strong sense of belonging. While there are challenges that need to be addressed, the state’s high literacy rate, strong educational infrastructure, and government support have created a conducive environment for entrepreneurship to thrive.