In the context of the Fourth Industrial Revolution, knowledge transfer plays a strategic role, positioned as a core resource determining the competitive capacity of enterprises through the systematic transformation of knowledge across sources. In Vietnam, while some large corporations have implemented internal knowledge management policies, most enterprises still lack full awareness of the critical importance of this pivotal activity. The study “Experiences in Knowledge Transfer of Global E-commerce Enterprises and Recommendations for Vietnam” aims to systematize the theoretical foundations of knowledge transfer and synthesize practical insights from global enterprises. It draws lessons and proposes solutions for application by Vietnamese businesses, grounded in a scientific methodology that includes secondary data collection from reputable academic sources and the application of analytical methods such as synthesis, induction, deduction, and comparison to ensure objectivity and comprehensiveness.