Sustainability has become a critical focus for textile industries amid growing demand for eco-friendly products, yet there is limited empirical research on its direct impact on organizational excellence. While prominent textile companies in Southern Tamil Nadu have adopted the farm-to-fiber approach and implemented sustainable practices, the impact of these initiatives on operational efficiency, employee satisfaction, brand reputation, and long-term success remains underexplored. Understanding this relationship is vital for refining sustainability strategies, enhancing organizational excellence, and guiding industry-wide adoption of best sustainability practices, which merits this research study. A convenience sample of 134 employees from lifestyle apparel manufacturers in Southern Tamil Nadu was examined, revealing that sustainability practices play a pivotal role in driving organizational excellence. This study employs the 3Ps framework (People, Planet, and Profit) to propose tailored strategies for enhancing sustainable manufacturing and promoting organizational excellence.